A treatment guide analyzed biologics, injectable medications made from living cells that specifically target parts of the immune system, and their treatment efficacy for psoriasis. Four classes of biologics are currently available for treating psoriasis: TNF-alpha blockers, IL-12/23 inhibitors, IL-17 inhibitors, and IL-23 inhibitors. Each class works by blocking different immune system messengers and varies in dosing regimen and side effects.

Candidates for biologics typically have moderate to severe psoriasis, though the treatment may also be considered for cases with significant impact on smaller skin areas. People with active cancer, untreated infections, or generally poor health should avoid biologics. Side effects may include increased risk of infections and malignancies, and for IL-17 blockers, a heightened risk of inflammatory bowel disease. Despite these risks, biologics are considered safe with regular dermatological follow-up and blood monitoring. Most biologics are self-injectable using auto-injector pens for convenience. While not a permanent cure, biologics can offer long-term, effective management of psoriasis symptoms.

Reference: Zeichner J. Treatment guide: Biologics for psoriasis. Medical News Today. Updated March 19, 2024. Accessed March 28, 2024. https://www.medicalnewstoday.com/articles/biologics-for-psoriasis