Researchers of a study conducted a multi-omics analysis of host-microbe interactions in psoriasis, revealing key associations between disease severity and specific microbial and host gene interactions. Analyzing data from 116 psoriasis patients and 102 healthy individuals, researchers found distinct skin transcriptomes in psoriatic lesions compared to non-lesional and healthy skin. They identified six gene modules, one linked to higher psoriasis area and severity index (PASI) scores and enriched in inflammation-related pathways.

The study found 13 microbial species enriched in psoriatic lesions, with Corynebacterium simulans abundant in moderate and severe PASI categories and positively correlating with CD4 T cells, dendritic cells, and keratinocytes, while Cutibacterium acnes was less abundant. Significant interactions between the skin microbiome and gene expression, particularly involving IFN-inducible genes, were observed. Two distinct microbial clusters in psoriatic lesions were identified, suggesting that concurrent microbiota modulation and immunomodulatory therapies could benefit patients with psoriasis. These findings highlight the importance of understanding host-microbe interactions in developing targeted psoriasis treatments.

Reference: Sai Lomte T. New study links psoriasis severity to skin microbiome dysbiosis. News Medical. Published June 28, 2024. Accessed July 12, 2024. https://www.news-medical.net/news/20240628/New-study-links-psoriasis-severity-to-skin-microbiome-dysbiosis.aspx