A recent study conducted using data from the UK Biobank has identified a significant association between new-onset psoriasis and exposure to four major air pollutants: PM2.5, PM10, nitrogen dioxide (NO2), and nitrogen oxides (NOx). The researchers, who followed participants for a median of 11.9 years, found that increased exposure to these pollutants corresponded with a 19% to 47% higher risk of developing psoriasis for each step up in exposure quartiles. Notably, individuals with a high genetic risk for psoriasis saw their risk double with increased pollution exposure.

The study’s findings align with a growing body of research linking air pollution to various inflammatory diseases. The commentary accompanying the study suggests that while reducing pollution levels is ideal, clinicians may need to explore medical interventions for high-risk patients. Further research into the interactions between air pollution, genetics, and inflammatory skin diseases is necessary to develop effective preventive therapies. However, practical prevention strategies remain limited, highlighting an urgent need for more research to guide clinical recommendations as air quality continues to be impacted by climate change.

Reference: Gever J. Psoriasis Joins List of Diseases Tied to Air Pollution. MedPage Today. Published July 16, 2024. Accessed August 16, 2024. https://www.medpagetoday.com/dermatology/psoriasis/111103