Psoriasis, a skin condition, has been linked to an increased risk of cardiovascular events and cardiovascular risk factors, alongside the potential association with diabetes mellitus (DM). However, conflicting findings exist regarding this connection, and nationwide data on the risk of new-onset DM in patients with psoriasis are lacking. To address this gap, a Danish study tracked over 4.6 million individuals for up to 13 years, identifying 52,613 patients with psoriasis, including 6,784 with severe psoriasis. The study found that the incidence rates of new-onset DM were elevated in patients with psoriasis compared to the reference population, with higher rates observed in those with severe psoriasis.

The findings underscore a significant association between psoriasis and increased incidence rates of new-onset DM, even after adjusting for confounding factors. These results contribute to understanding the complex interplay between psoriasis and metabolic conditions like DM, highlighting the importance of comprehensive management strategies for patients with psoriasis to mitigate associated risks.

Reference: Khalid U, Hansen PR, Gislason GH, et al. Psoriasis and new-onset diabetes: a Danish nationwide cohort study. Diabetes Care. 2013;36(8):2402-7. doi: 10.2337/dc12-2330.