A recent study by researchers at Case Western Reserve University School of Medicine has identified the protein NF-kB c-Rel as a key factor in intensifying the symptoms of psoriasis, a painful inflammatory skin condition. The research explored how c-Rel contributes to dendritic cell (DC) function and how it is activated by immune signals through Toll Like Receptor 7 (TLR7), which regulates inflammation. The study found that the absence of c-Rel reduced inflammation and alleviated the red, scaly patches characteristic of psoriasis, suggesting that targeting this protein could lead to more effective treatments.

The researchers examined both skin samples from patients with psoriasis and a mouse model, discovering that higher c-Rel levels were present in the psoriasis-affected skin. Mice lacking c-Rel showed significant protection from developing psoriasis and less inflammation. Principal investigator Parameswaran Ramakrishnan believes that focusing on c-Rel and TLR7 could pave the way for targeted treatments to reduce psoriasis symptoms. The study also suggests that viral infections, such as HIV, HPV, and HCV, which activate TLR7, may play a role in worsening psoriasis. Future research will explore the potential links between TLR7-c-Rel signaling and other diseases like lupus and diabetes.

Reference: Zamora P. New Case Western Reserve University study identifies key protein’s role in psoriasis. The Daily. Accessed May 14, 2025. https://thedaily.case.edu/new-case-western-reserve-university-study-identifies-key-proteins-role-in-psoriasis/