A recent study aimed to investigate whether elevated plasma triglycerides are linked to a higher risk of psoriasis, a chronic inflammatory skin disorder. Using data from the Copenhagen General Population Study (CGPS) and genetic analysis involving known triglyceride-altering genetic variants, researchers assessed the association between plasma triglyceride levels and psoriasis risk. They found that individuals with higher plasma triglyceride levels had a significantly increased risk of psoriasis, both in observational analysis and Mendelian randomization analysis.

These findings suggest that elevated plasma triglycerides may contribute to the development of psoriasis. They highlight the potential role of triglyceride-rich lipoproteins in promoting low-grade systemic inflammation, a key feature of psoriasis pathology. The study underscores the importance of understanding the underlying mechanisms linking lipid metabolism and inflammation in psoriasis development. It offers insights into potential therapeutic targets for managing this chronic skin disorder.

Reference: Greve AM, Wulff AB, Bojesen SE, Nordestgaard BG. Elevated plasma triglycerides increase risk of psoriasis: A cohort and Mendelian randomization study. Br J Dermatol. 2024 Feb 27:ljae089. doi: 10.1093/bjd/ljae089. Epub ahead of print. PMID: 38411598.