A recent study revealed an increased risk of psoriatic arthritis (PsA) among female patients with severe skin psoriasis, especially those with nail involvement and those requiring oral systemic therapy. Analyzing data from 330 patients with psoriasis, researchers found significant risk factors for PsA development included female gender, nail involvement, severe skin psoriasis, and the use of oral systemic treatments. Notably, 25% of the cohort was diagnosed with PsA over an average follow-up of 10.2 years, highlighting the complex nature of psoriasis progression to PsA.

The research also noted that the average age for PsA diagnosis was 54.2 years, predominantly among females, with the time between psoriasis and PsA onset varying, underscoring the need for ongoing monitoring. Race and ethnicity did not significantly affect PsA risk, nor did the presence of common comorbidities like hypertension, diabetes, and dyslipidemia show notable differences between those with only psoriasis and those who developed PsA. These findings emphasize the importance of healthcare providers incorporating these predictive factors into their patient evaluations and management plans to better anticipate and manage the progression from psoriasis to PsA.

Reference: Grossi G. From Psoriasis to PsA: Study Identifies Predictive Factors for Development. AJMC. Updated February 20, 2024. Accessed May 2, 2024. https://www.ajmc.com/view/from-psoriasis-to-psa-study-identifies-predictive-factors-for-development