Understanding the intricate role of cytokines in psoriasis pathogenesis is crucial for developing effective treatments. Elevated levels of inflammatory cytokines contribute to the characteristic features of the disease, driving its severity. Genome-wide association studies have identified genetic variants associated with cytokines and their receptors, further implicating these molecules in psoriasis development. Targeting specific cytokines has revolutionized psoriasis treatment, highlighting the significance of unraveling their role in disease progression. The complex cytokine networks involved in psoriasis underscore the multifaceted nature of the condition. Identifying key cytokines driving pathogenesis presents promising opportunities for the development of targeted therapies. By delving deeper into these cytokine pathways, researchers aim to refine treatment approaches, ultimately enhancing outcomes for individuals grappling with this chronic skin ailment.

Reference: Baliwag J, Barnes DH, Johnston A. Cytokines in psoriasis. Cytokine. 2015;73(2):342-50. doi: 10.1016/j.cyto.2014.12.014.